| May 23, 2022 |
 Philadelphia Flyers | Linus Sandin | Signed to Standard Contract | |
 Chicago Blackhawks | Filip Roos | Signed to Entry-Level Contract | ✔ |
|
| May 22, 2022 |
 St. Louis Blues | Charlie Lindgren | Emergency Loan  | |
 Colorado Avalanche | Trent Miner | NHL | |
| Colorado Avalanche | Hunter Miska | Minors  | |
 Buffalo Sabres | Olivier Nadeau | Signed to Entry-Level Contract | |
 Detroit Red Wings | Steven Kampfer | Signed to Standard Contract | ✔ |
 Toronto Maple Leafs | Mark Giordano | Signed to 35+ Contract | |
|
| May 21, 2022 |
 Pittsburgh Penguins | Bryan Rust | Signed to Standard Contract | |
 Tampa Bay Lightning | Anthony Richard | NHL | |
| Tampa Bay Lightning | Maxime Lagacé | NHL | |
| Tampa Bay Lightning | Gabriel Fortier | NHL | |
| Tampa Bay Lightning | Remi Elie | NHL | |
| Tampa Bay Lightning | Fredrik Claesson | NHL | |
| Tampa Bay Lightning | Alex Barré-Boulet | NHL | |
| Tampa Bay Lightning | Jaydon Dureau | Signed to Entry-Level Contract | |
 Calgary Flames | Ilya Nikolayev | Signed to Entry-Level Contract | |
| Detroit Red Wings | Taro Hirose | Signed to Standard Contract | |
|
| May 20, 2022 |
| Tampa Bay Lightning | Simon Ryfors | NHL | |
| Tampa Bay Lightning | Darren Raddysh | NHL | |
| Tampa Bay Lightning | Cole Koepke | NHL | |
| Tampa Bay Lightning | Gage Goncalves | NHL | |
| Tampa Bay Lightning | Hugo Alnefelt | NHL | |
| St. Louis Blues | Steven Santini | Minors | |
 San Jose Sharks | Mitchell Russell | Signed to Entry-Level Contract | ✔ |
 Columbus Blue Jackets | Joonas Korpisalo | Signed to Standard Contract | |
|
| May 19, 2022 |
| Colorado Avalanche | Hunter Miska | NHL | |
| Philadelphia Flyers | Nick Seeler | Signed to Standard Contract | |
|
| May 18, 2022 |
 Edmonton Oilers | Colton Sceviour | NHL | |
| Colorado Avalanche | Justus Annunen | Minors | |
| Calgary Flames | Juuso Välimäki | Emergency Loan | |
 Dallas Stars | Fredrik Olofsson | Signed to Standard Contract | ✔ |
|
| May 17, 2022 |
| St. Louis Blues | Steven Santini | NHL | |
| Edmonton Oilers | Stuart Skinner | NHL | |
| Edmonton Oilers | Dmitri Samorukov | NHL | |
| Edmonton Oilers | Markus Niemeläinen | NHL | |
| Edmonton Oilers | Brad Malone | NHL | |
| Edmonton Oilers | Dylan Holloway | NHL | |
| Edmonton Oilers | Seth Griffith | NHL | |
| Edmonton Oilers | Philip Broberg | NHL | |
| Colorado Avalanche | Justus Annunen | NHL | |
| St. Louis Blues | Vadim Zherenko | Signed to Entry-Level Contract | |
| Philadelphia Flyers | Adam Ginning | Signed to Entry-Level Contract | |
|
| May 16, 2022 |
 Washington Capitals | Joe Snively | Activated from LTIR | |
| Pittsburgh Penguins | Radim Zohorna | Minors | |
| Pittsburgh Penguins | Louis Domingue | Placed on roster from roster emergency exception | |
| Pittsburgh Penguins | Alex D'Orio | Placed on roster from emerg. loan | |
| Edmonton Oilers | Kyle Turris | Activated from LTIR | |
 New York Rangers | Gustav Rydahl | Signed to Standard Contract | ✔ |
| Calgary Flames | Adam Klapka | Signed to Entry-Level Contract | ✔ |
|
