| Jan 20, 2021 |
 Philadelphia Flyers | Morgan Frost | Injured Reserve  | |
 Dallas Stars | Joel Kiviranta | Activated from SOIR | |
| Dallas Stars | Nicholas Caamano | Activated from SOIR | |
|
| Jan 19, 2021 |
 Buffalo Sabres | Kyle Okposo | Injured Reserve | |
|
| Jan 18, 2021 |
 Anaheim Ducks | Max Jones | Activated from IR | |
 San Jose Sharks | Radim Simek | Activated from IR | |
 Boston Bruins | Ondrej Kase | Injured Reserve | |
|
| Jan 17, 2021 |
 Arizona Coyotes | Oliver Ekman-Larsson | Injured Reserve | |
 Pittsburgh Penguins | Michael Matheson | Injured Reserve | |
 St. Louis Blues | Robert Bortuzzo | Injured Reserve | |
|
| Jan 16, 2021 |
| San Jose Sharks | Maxim Letunov | Activated from SOIR | |
| Philadelphia Flyers | Tanner Laczynski | Activated from SOIR | |
|
| Jan 15, 2021 |
 Edmonton Oilers | Mike Smith | Long-Term Injured Reserve | |
|
| Jan 14, 2021 |
| Boston Bruins | Kevan Miller | Activated from IR | |
| Boston Bruins | Brad Marchand | Activated from IR | |
| Anaheim Ducks | Ryan Kesler | Long-Term Injured Reserve | |
 Detroit Red Wings | Danny DeKeyser | Activated from IR | |
 Chicago Blackhawks | Jonathan Toews | Long-Term Injured Reserve | |
| Chicago Blackhawks | Kirby Dach | Long-Term Injured Reserve | |
|
| Jan 13, 2021 |
| San Jose Sharks | Radim Simek | Injured Reserve | |
| St. Louis Blues | Vladimir Tarasenko | Long-Term Injured Reserve | |
 Winnipeg Jets | Bryan Little | Long-Term Injured Reserve | |
 Vancouver Canucks | Micheal Ferland | Long-Term Injured Reserve | |
|
| Jan 12, 2021 |
 Florida Panthers | Tommy Cross | Season-Opening Injured Reserve | |
 New York Islanders | Johnny Boychuk | Long-Term Injured Reserve | |
| Dallas Stars | Stephen Johns | Long-Term Injured Reserve | |
| Dallas Stars | Ben Bishop | Long-Term Injured Reserve | |
| Dallas Stars | Joel Kiviranta | Season-Opening Injured Reserve | |
| Dallas Stars | Nicholas Caamano | Season-Opening Injured Reserve | |
 Columbus Blue Jackets | Brandon Dubinsky | Injured Reserve | |
| Anaheim Ducks | Brendan Guhle | Long-Term Injured Reserve | |
| Vancouver Canucks | Jayce Hawryluk | Long-Term Injured Reserve | |
 Washington Capitals | Henrik Lundqvist | Long-Term Injured Reserve | |
| Washington Capitals | Michal Kempný | Long-Term Injured Reserve | |
| Washington Capitals | Beck Malenstyn | Season-Opening Injured Reserve | |
| Winnipeg Jets | Dominic Toninato | Long-Term Injured Reserve | |
| San Jose Sharks | Maxim Letunov | Season-Opening Injured Reserve | |
| Pittsburgh Penguins | Zach Trotman | Season-Opening Injured Reserve | |
 Vegas Golden Knights | Jiri Patera | Season-Opening Injured Reserve | |
| New York Islanders | Michael Dal Colle | Injured Reserve | |
 Los Angeles Kings | Martin Frk | Injured Reserve | |
 Minnesota Wild | Mats Zuccarello | Injured Reserve | |
| Minnesota Wild | Marco Rossi | Season-Opening Injured Reserve | |
| Minnesota Wild | Alex Stalock | Injured Reserve | |
| Edmonton Oilers | Oscar Klefbom | Long-Term Injured Reserve | |
 New Jersey Devils | Nico Hischier | Injured Reserve | |
 Ottawa Senators | Vitaly Abramov | Season-Opening Injured Reserve | |
| Anaheim Ducks | Max Jones | Injured Reserve | |
| Detroit Red Wings | Jared McIsaac | Season-Opening Injured Reserve | |
| Chicago Blackhawks | Alexander Nylander | Long-Term Injured Reserve | |
|
