| Sep. 23, 2022 |
 Vegas Golden Knights | Reilly Smith | Activated from IR | |
| Vegas Golden Knights | Brett Howden | Activated from IR | |
 Vancouver Canucks | Tucker Poolman | Activated from IR | |
| Vancouver Canucks | Nils Höglander | Activated from IR | |
 Pittsburgh Penguins | Drake Caggiula | Activated from IR | |
 Boston Bruins | Brett Harrison | Junior | |
 Arizona Coyotes | Maveric Lamoureux | Junior | |
 Ottawa Senators | Jorian Donovan | Signed to Entry-Level Contract | |
|
| Sep. 22, 2022 |
 Buffalo Sabres | Malcolm Subban | Activated from IR | |
 Seattle Kraken | Brandon Tanev | Activated from IR | |
 San Jose Sharks | Markus Nutivaara | Activated from IR | |
| San Jose Sharks | Kevin Labanc | Activated from IR | |
 Chicago Blackhawks | Connor Murphy | Activated from IR | |
| Chicago Blackhawks | Jujhar Khaira | Activated from IR | |
 Edmonton Oilers | Ryan McLeod | Signed to Standard Contract | |
|
| Sep. 21, 2022 |
 Philadelphia Flyers | Samu Tuomaala | Loan | |
 Los Angeles Kings | Sean Walker | Activated from IR | |
| Los Angeles Kings | Drew Doughty | Activated from IR | |
 Columbus Blue Jackets | Daniil Tarasov | Activated from IR | |
| Boston Bruins | Jakub Zboril | Activated from IR | |
 New York Islanders | Parker Wotherspoon | Signed to Standard Contract | |
 Calgary Flames | Brett Ritchie | Signed to Standard Contract | ✔ |
| New York Islanders | Cory Schneider | Signed to 35+ Contract | ✔ |
| New York Islanders | Nikita Soshnikov | Signed to Standard Contract | ✔ |
| Calgary Flames | Adam Ruzicka | Signed to Standard Contract | |
| Columbus Blue Jackets | Mikael Pyyhtiä | Recalled from loan | |
| Ottawa Senators | Shane Pinto | Activated from IR | |
|
| Sep. 20, 2022 |
 Florida Panthers | Patrick Giles | Signed to Entry-Level Contract | ✔ |
| Arizona Coyotes | Barrett Hayton | Signed to Standard Contract | |
 Colorado Avalanche | Nathan MacKinnon | Signed to Standard Contract | |
 Anaheim Ducks | Jakob Silfverberg | Activated from IR | |
|
| Sep. 19, 2022 |
 Dallas Stars | Nils Lundkvist | Traded from New York Rangers | ✔ |
|
| Sep. 15, 2022 |
 Toronto Maple Leafs | Dennis Hildeby | Loan | |
| Arizona Coyotes | Conor Timmins | Activated from IR | |
 Winnipeg Jets | Cole Perfetti | Activated from IR | |
| Los Angeles Kings | Sean Durzi | Signed to Standard Contract | |
 Washington Capitals | Ludwig Persson | Recalled from loan | |
 New York Rangers | Adam Sýkora | Recalled from loan | |
| New York Rangers | Adam Edström | Recalled from loan | |
|
| Sep. 14, 2022 |
| Ottawa Senators | Tyler Motte | Signed to Standard Contract | ✔ |
|
| Sep. 13, 2022 |
 St. Louis Blues | Jordan Kyrou | Signed to Standard Contract | |
|
| Sep. 12, 2022 |
| Colorado Avalanche | Evan Rodrigues | Signed to Standard Contract | ✔ |
|
| Sep. 10, 2022 |
| Los Angeles Kings | Michael Anderson | Signed to Standard Contract | |
|
| Sep. 8, 2022 |
 Montreal Canadiens | Cayden Primeau | Signed to Standard Contract | |
|
| Sep. 7, 2022 |
| Ottawa Senators | Tim Stützle | Signed to Standard Contract | |
| Montreal Canadiens | Kirby Dach | Signed to Standard Contract | |
|
| Sep. 5, 2022 |
| Ottawa Senators | Erik Brännström | Signed to Standard Contract | |
|
| Sep. 3, 2022 |
| San Jose Sharks | Evgeny Svechnikov | Signed to Standard Contract | ✔ |
|
| Sep. 2, 2022 |
| Vancouver Canucks | J.T. Miller | Signed to Standard Contract | |
| Edmonton Oilers | Ryan Murray | Signed to Standard Contract | ✔ |
|
