The Rookies need Veteran shelter and Kadri needs Defensively Responsible Wingers:

Ruzicka-Lindholm-Toffoli
Huberdeau-Backlund-Duehr
Mangiapane-Kadri-Coleman
Dube-Lewis-Coronato

And I’d play Vladar over Markstrom

I could live with that. Though I disagree with some of the mix, if those are the players playing I would be happy.

Depends whether you believe Hunderdeau would be better with a Left Shot RW or a Right Shot RW, but Duehr is hot right now , so deserves more minutes and I kept familiar pairings for consistency:

Lindholm-Toffoli
Huberdeau-Backlund
Mangiapane-Coleman

I also give Coronato a decent Winger in Dube and Coronato could Centre that 4th line with Lewis at RW

I believe that Hubie is naturally better suited for a Left Shot Rightwing, because he usually slows the play down or does his spin-o-Rama, but suits a left shot coming back towards him in a one timer spot.
I also think that he bet much needs a North South Center to drive play and open up space for him to be creative. My long term hope is that it could be Dube, or even better Zary.
The combination of Pellts and Scoro could be a similar mold to JH and MT which might be great for Lindholm to build with (again in the long run).
I don’t love your first two pairs, even though it has been working (because it’s what we have).

I'd like to see Kadri be moved off Centre to play the same RW role Matthew Tkachuk did for us: Net Front Presence + Agitator (especially the goalie), Shot Tipper & Sniper and also Good at Drawing Penalties

Ruzicka/Pelletier - Lindholm - Toffoli
Huberdeau - Backlund/Dube - Kadri/Mangiapane
Mangiapane/Coleman - Dube/Backlund - Coleman/Kadri
Ritchie/Pelletier/Ruzicka - Lewis - Duehr/Coronato

Huberdeau-Lindholm-Kadri and Toffoli-Lindholm-Kadri would both be interesting to see as well = Load Up

I think Kadri is too much of a free lancer to be a good “wingman”. But I do agree with your point.

I was thinking about it again last night. What if we went back to the start of the year….
Ruzie - Lindy - Toffoli (correct me if I’m wrong but didn’t Ruzie go PPG?)
Mang - Kadri - Dube (they might lack a true playmaker, but tenacity makes up for it)
Hubie - Backs - Coronato (Backs can protect Coronato, and gives Hubie another young guy with speed and a shot to feed)
Pellts - Lewis - Coleman (An actual threat of a fourth line who is very defensively responsible)

If you need to get some size in the lineup, Looch replaces Pellts, and Ritchie replaces Coronato. But it is a very deep lineup, that has scoring threats on all four lines.

He's too much of a "Lone Wolf/Freelancer" to be a Centre, but if he stays at Centre, this is my recommendation:

Pelletier/Ruzicka - Lindholm - Toffoli
Huberdeau - Backlund - Ruzicka/Dube
Mangiapane - Kadri - Coleman
Lewis/Ritchie - Dube/Ruzicka - Duehr/Coronato